The migrants, mostly young men and women with their luggage and small children, departed from a bus terminal in the northern city of San Pedro Sula headed toward the Guatemalan border, according to reports.
"I am leaving with my whole family. There is no work here. There is nothing to do, and if you find a job they only pay you 100 lempiras a day" said a woman who identified herself as Cristina.
Wednesday's group marks the first caravan to depart Honduras in 2020, as the nation suffers the largest recorded economic decline in its history after six months of strict lockdown measures aimed at slowing the spread of the novel coronavirus.
In October 2018, US President Donald Trump ordered soldiers to the border with Mexico in response to caravans of Central American migrants who were moving north to the United States.
Trump, who railed against unauthorized immigration in his successful 2016 presidential campaign, claimed that the troops were needed to secure the border against the migrants but critics said the move was a political stunt in the lead up to US congressional elections that November.